Diabetes Mellitus, as a widespread chronic disease, gives rise to serious acute and chronic complications. The disease, not only affects the life quality of the patients negatively but also causes high costs for health and work systems. There exist serious insufficiencies in diabetes diagnosis and treatment modalities. In this aspect, new researches about prevention, diagnosis, and treatment of diabetes are done in a widespread manner. Among these researches, nanotechnology-based studies about diabetes gain attention. Nanotechnology studies in diabetes management focus on diagnostic methods, glucose monitoring, insulin, and drug delivery, and islet implantation. In this review, a general view about the pointed out topics have been mentioned.