Leiomyosarcoma is the most common soft tissue sarcoma and is described as a malignant tumor of mesenchymal cells. It is rarely found as primary, secondary, or metastatic in origin in the eye and adnexa. To the best of our knowledge, a metastatic leiomyosarcoma involving the conjunctiva has not been reported in the literature. We report a case of a 35-years-old gentleman, with a prior history of leiomyosarcoma involving the anterior chest wall with pulmonary metastasis presenting to us with a rapidly increasing conjunctival mass involving his left eye. After a detailed clinical evaluation, the lesion was surgically excised. We discuss the clinical features and histopathology characteristics supported by immunohistochemistry analysis of this rare case of conjunctival metastasis from leiomyosarcoma with a review of metastatic tumors of the conjunctiva.
Conjunctival Metastasis, Leiomyosarcoma, Anterior Chest Wall
Metastatic tumor to conjunctiva is a rare entity and it may often reflect poor prognosis due to an advanced state of the primary malignancy. They constitute <1% of all conjunctival tumors . Leiomyosarcoma is a malignant tumor of mesenchymal cells with smooth muscle differentiation. Primary leiomyosarcoma originating from the eye and adnexa has been reported from conjunctiva, uvea, and orbit [2-4]. Metastatic leiomyosarcoma is extremely rare and has been described in orbit, eyelid, and choroid in literature [5-8]. To the best of our knowledge, leiomyosarcoma metastatic to conjunctiva has not been reported previously. We describe a case of a 35-years-old gentleman who presented to us with a rapidly growing nodule on his bulbar conjunctiva with a history of biopsy-proven left-sided anterior chest wall leiomyosarcoma with a review of metastatic tumors of the conjunctiva. The patient’s consent was obtained for use of his clinical photographs for academic and research purposes. The case report adheres to the ethical principles outlined in the Declaration of Helsinki as amended in 2013.