Pregnancy Outcomes in Women with Extremely High sFlt- 1/PIGF Ratio: Case Series

Abstract

Background: Preeclampsia (PE) is a multisystem disorder, usually defined as the development of hypertension and proteinuria after 20 weeks of pregnancy. The sFlt-1/PlGF ratio has been widely studied as a diagnostic and prognostic marker of preeclampsia and other manifestations of placental dysfunction. A sFlt-1/PlGF ratio greater than 85 for early PE, less than 34 weeks of gestation suggests a high risk of PE requiring close clinical monitoring.
Objective: To evaluate the maternal and perinatal outcomes of pregnancies with an extremely high sFlt-1/PlGF ratio.
Case Presentation: The analysis included data on placental growth factor and soluble fms-like tyrosine kinase serum levels, measured during 2017-2020 in 128 pregnant women. Here we present 8 cases of women with a numerical ratio greater than 850.
In all 100% of cases, the signs of obstetric angiogenic catastrophe requiring imminent delivery developed soon.
Conclusion: We observed a trend for worsening perinatal outcomes in women with an extremely high sFlt-1/PlGF of ≥850.