A CD20 and CD3 negative variant of Lymphoma Cutis: A diagnostic challenge

Abstract

Introduction: Cutaneous lymphomas (CLs) represent the clonal proliferation of neoplastic T or B lymphocytes and rarely of natural killer (NK cells) or plasmacytoid dendritic cells the diagnosis and classification of PCLs should always be based on a combination of clinical, histological, immunophenotypically and genetic. Treatment should be selected, taking into account the type of lymphoma and its stage and should be adapted to risk. Skin-directed therapies are the first choice for treating the early stages of the disease.
Case presentation: We present a case of cutaneous lymphoma on a 32-year-old woman. The diagnosis was established based on history, physical examination, histopathology, and immunohistochemistry (IHC) examination, which showed CD20 negative and CD3 negative. Patients were treated with an emollient and topical corticosteroid, as the results of the hyperpigmented plaques lesions regressed, and the patients are symptom-free at regular follow up 6-month later.
Conclusion: Topical corticosteroids can be used to treat refractory cases in early-stage disease. An important point in the diagnosis and classification of Primary Cutaneous Lymphoma (PCL) is based on a combination of clinical data and histopathological.