Acute Inflammatory Response after Novolimus Eluting Bioresorbable Scaffold and Novolimus Eluting Stent Implantation in Al-Najaf Cardiac Center Patients: A Comparative Study

Abstract

Background: Inflammation plays an important role in the development of acute coronary syndromes (ACS) and post percutaneous coronary intervention (PCI) response due to vascular injury triggered by intervention procedures. During the thrombus formation, the progression of inflammation, neointimal proliferation, a lymphocyte/macrophage infiltration can occur either immediately after or in the hours following the series as an inflammatory response to coronary stent implantation. Bioresorbable vascular scaffold (BVS) thrombosis is a problem with this device in both acute to very late thrombosis. Acute and sub-acute BVS thrombosis is linked with conditions of implantation as shown in drug-eluting stent (DES).
Objective: To assess the differences between the two types of coronary systems, Novolimus Bioresorbable scaffold and Novolimus eluting stent implantation associated with acute inflammatory response triggered by percutaneous coronary intervention in coronary artery disease patients.
Patients and Methods: A total of forty-four diabetic patients (type II) with unstable angina (29 men and 15 women, aged 43 to 70 years old) were included in this study. All patients submitted to elective PCI at AL-Najaf center for cardiac surgery and Tran’s catheter therapy between January and July 2015. The patients were randomized into two groups in a single-blind study. (Group 1) includes Twenty diabetes patients with coronary artery stenosis undergoing Novolimus Bioresorbable coronary scaffold implantation (Group 2) includes Twenty four diabetes patients with coronary artery stenosis undergoing Novolimus eluting stent implantation. Serum blood samples were drawn from peripheral vein directly before implantation, as well as 12 and 24 hours after implantation to use for measurement of IL-6, PTX3, MMP-9, cTn-I, and C5a by sandwich ELISA method.
Results: This comparison of Novolimus eluting coronary stent and Novolimus Bioresorbable coronary scaffold implantation showed a significant increase in serum levels of IL-6, PTX3 at 12 and 24 hrs. and MMP-9 at 24 hrs. (p<0.05) in group 1 as compared with group 2, while the serum levels of cTn-I and C5a were insignificantly changed between two groups of coronary systems (p>0.05).
Conclusions: The Novolimus Bioresorbable scaffold with thick strut causes a more marked inflammatory response as compared with Novolimus eluting stent with a thin strut.