Analysis of 23 Patients with HIV Infection and COVID-19: Descriptive Study

Abstract

The clinical characteristics, diagnosis methods, medical prognosis, treatment alternatives and prophylaxis of coronavirus SARS-CoV-2 infection in HIV (Human immunodeficiency virus) infected individuals are very similar in patients under HAART with undetectable viral load and CD4+ > 200 cell/μl. The mean incubation time is 5 days (range 2 to 14 days). In HIV-seropositive patients, with high viral load and CD4 < 200 cell/μl, the time between infection for coronavirus and the onset of symptoms is minor. In the general population, 70% to 80% of individuals infected by SARS-CoV-2 develop a mild to moderate disease; 20% to 25% severe forms and 5% develop very severe clinical compromise that requires intensive therapy unit income. In HIV-positive patients these percentages would be 66%, 22% y 12%, respectively. Here we present a series of 23 HIV-seropositive patients coinfected by coronavirus SARS-CoV-2; we analyzed the epidemiology, clinical manifestations and the evolution related with both infections.