Antibiotic Resistance in Children with Urinary Tract Infection at Al-Mahmodyiah General Hospital: Descriptive Study

Abstract

Background: The urinary tract infection (UTI) is common in children under 15 years especially in females more than 1 year, that may lead many morbidities such as chronic infection, weight loss and renal failure. The aim of this study is therefor to assess the causative microorganism of UTI and to evaluate the empirical antibiotic treatment of UTI by culturing the causative organism and antibiotic resistance patterns of urine examination for children visits the outpatient clinic in Al-Mahmodyiah hospital.

Methods: A total of 638 children with positive urine culture were included in the study. Antibiotic susceptibility testing was performed with Vitek 2 Compact for 10 commonly used antimicrobials.

Results: Age ranged from 0 - 15 years, divided into 4 main groups. Escherichia coli 376 (59%), were the most common pathogens. For all isolated microorganisms, a high level of resistance was found against cefepim, ampicillin, and trimethoprim/sulfamethoxazole. A high sensitivity was noted for meropenem, nitrofurantoin, gentamicin and amikacin

Conclusions: Antibiotic resistance in pediatric UTI patients is high. The susceptibility of uropathogen antimicrobial resistance patterns to antimicrobials varies with age. In order to choose the best course of action for treating a UTI, it is necessary to regularly examine the trends in antibiotic susceptibility patterns.