Correlation between Highly Sensitive C-Reactive Protein Level in Cases of Preeclampsia with or without Intrauterine-Growth Restriction

Abstract

Preeclampsia is a hypertensive disorder that affects 4% of pregnant women, in which the exact cause cannot identified it is one of the major causes of maternal and fetal morbidity and mortality, also it puts a burden on perinatal outcome as prematurity and intrauterine growth restriction. Continuous search for predictive markers of severe PE is important and can be used to target high risk women for effective preventive treatment.
Aim of study: To evaluate that Highly Sensitive C-Reactive Protein can be used as predictive factor for severity of preeclampsia and whether it can be used to predict development of Intrauterine growth restriction.
Patients and methods: This is a cross-sectional study includes 80 pregnant women with their age 18-35 years, their gestational age range between 32-40 weeks, admitted to AL-Zahraa teaching hospital in Najaf, whose diagnosed as PE based on blood pressure measurement and proteinuria. Full history and clinical examination were performed, venous blood aspirated for each woman for biochemical analysis, Liver functions tests, Renal function tests, Highly Sensitive C- Reactive Protein, and Doppler ultrasound.
Results: The patients divided into those with mild PE and severe PE, with or without IUGR. No significant difference between the level of Highly Sensitive C-Reactive Protein and the severity of PE as p value was (0.779), but there is significant difference between the presence of IUGR and the level of Highly Sensitive C-Reactive Protein when it is ≥ 2 mg/L as the p value was (0.020). Conclusion: We conclude that Highly Sensitive C-Reactive Protein is not significantly associated with the severity of Preeclampsia but associated with intra uterine growth restriction.