Correlation between Serum Caspase-8 with Clinical and Laboratory Manifestation of SLE

Abstract

Background: SLE is a multisystem disease that is due to dysregulation of immune system and apoptosis process. Caspase-8 is one of the important enzymes in the apoptotic pathways.
Aim: In this study we try to assess correlation between serum levels of this enzyme with some clinical and laboratory manifestations of SLE.
Method: We have enrolled 50 patients with SLE and measured their serum caspase-8 levels end have recorded some of the clinical and laboratory manifestation. Then we correlate these with corresponding serum caspase-8 levels.
Results and Conclusions: Only SLE duration showed significant correlation with serum caspase-8 level.