Hyperlipidemic is a medical condition with an accumulation in the blood of any or all of the lipid profiles and/or lipoproteins, hyperlipidemic consider as the most reason of coronary heart disease, stroke, high blood pressure and diabetes type 2. The widely use of plant derived component have great attention in the last years because the medicinal plants now used for different disease because it has active compounds such as glycosides, alkaloids and resins. However, there is a limit and contraindicated data about their action on decreasing the level of lipoproteins in the serum. In this study three different resins of different medicinal plant were used to evaluate cholesterol, TG, LDL, HDL and VLDL. Results of this study revealed that Aloe Vera resin extract has a major effect on LDL-C (p>0.05) similar to the action of atorvastatin, Boswell results showed an inconsiderable effect compared to the effect of Atorvastatin drug. Commiphora results showing that the anti-hyperlipidemic effect of Commiphora Mol resin was noticeable and has the same effect of atorvastatin on triglycerides(p>0.05) finally the combination effect only on total cholesterol and on HDL-C, (p>0.05) when compared to atorvastatin. Conclusions: These different derived plants are varied in their action on lowering lipoprotein levels of induced hyperlipidemic effect when compared with atorvastatin the anti-hyperlipidemic standard drug which effect on all lipids profile.