Evaluation of the Effect of Dexmedetomidine on Hemodynamic Changes and Recovery Time in Patients Undergoing Dilatation and Curettage

Abstract

Background: Because of the traditional use of propofol drugs for relaxation in dilatation and curettage is used. Recently, doctors have taken into consideration the importance of dexmedet?midine treatment. Since quantitative reports on the use of long-acting diuretics in the practice of dilatation and curettage, this study aimed to compare the effect of dexmedet?midine and placebo (normal saline) on the rate of patient recovery instead, the amount of pain in recovery and hemodynamic parameters, and the need for drugs and hypnosis drugs.
Methods: This double blind clinical trial was conducted between two groups of 50 patients with dexmedet?midine (D) and placebo (P). At first, group D received 1µg/kg dose of dexmedet?midine for 10 minutes and P group received 1µg/kg normal saline for 10 min. Then, 2 mg/kg fentanyl and both groups received 1.5 mg anesthetic Injecting propofol per kilogram to Ramsey relaxation score of 3-4, and during the hemodynamic operation, it was recorded and compared with the amount of opioid and propofol needed.
Results: In group D, the maximum blood pressure and minimum blood pressure in the 5th minute after the start of the operation were significantly different with the P group (P<0.05). Also, in group D, the heart rate was significantly different in the 5th and 10th min after surgery with P group (P<0.05). There was a significant difference between groups in D group with recovery group (P<0.05). Conclusion: Since the use of Dexmedetomidine in comparison with placebo has hemodynamic stability, the patient’s greater satisfaction and less pain in recovery, it is deduced that Dexmedet?midine is a suitable alternative for short-term surgery.