Energy drinks have become popular among people from all age groups because of the instant supply of energy and mental alertness. The main component of these high energy drinks is caffeine. Several studies have reported the negative effects of caffeine consumption in any form. Animal studies have shown the negative effects of energy drinks containing caffeine on cardiovascular, renal, and neuro-cognitive functions. There are no studies to evaluate the effects of energy drinks on renal function in the human population. The most famous energy drink in Iraq is the caffeinated energy drink, Tiger. The consumption of this drink has dramatically increased in Iraq. So, with this premise, the present study aimed to evaluate the effects of high energy drink (Tiger) on renal function. Forty-nine participants who had no history of any systemic illness, non-alcohol consumers, and non- smokers, who consumed high energy drink (Tiger) for at least 90 days and 49 age and sexmatched healthy participants who did not consume any high energy drink were recruited for the study. The baseline and post 90 days serum creatinine and blood urea were measured by using the kit-based method. The paired sample t-test was used to compare the baseline and the post 90 days of serum creatinine and blood urea levels. A p value <0.05 was significant. The serum creatinine and blood urea levels were significantly increased in the group of participants who consumed high energy drink (Tiger) at 90 days of high energy drink consumption. There was a significant change in the levels of serum creatinine and blood urea in the control group. The elevated levels of serum creatinine and blood urea are indicative of renal damage caused by the consumption of high energy drink (Tiger). The results of the present study suggest that indiscriminate use of high energy drinks should be stopped.