Flow Cytometry and Liquid Broth Microdilution Assay Evaluation of the Synergistic Activity of Eugenol with Current Antibiotics Against Eskape Clinical Strains

Abstract

Considering the increase in antibiotic-resistant (AR) bacterial strains and the lack of new antibiotics, alternative/complementary strategies need to be founded to solve the infections due to AR pathogens. A possible solution may be to combine existing antibiotics with phytochemicals to enhance their efficacy. The purpose of this study was to assess the synergy between eugenol and a set of antibiotics currently used for the treatment of infections produced by Gram positive and Gram negative strains.