Meningiomas (Grade II and III): Retrospective study in Basrah

Abstract

Background: Non benign meningiomas include atypical type (WHO grade II tumor) and anaplastic type (WHO grade III tumor). Usually, gross total resection (GTR) at the time of diagnosis is considered as the line of management, but subsequent prognosis and optimal management remain unclear. The study aimed to determine the characterized meningiomas features in Department of Neurosurgery, Al-Mauany Teaching Hospital, and Al-Basrah Teaching Hospital.

Methods: A retrospective study of patients with malignant meningioma in Neurosurgery Department from May 2019 to June 2024. This study included 51 newly diagnosed patients with malignant meningioma (30 females and 21 males, with the median age 49 years). We reviewed all histopathological reports of the patients. Data was collected from our patient’s archiving system. We evaluate in this work the correlation between the above prognostic factors and recurrence rate. As regards the extent of tumor resection, we include in this study all patients with total tumor resection which are collected from operative data or postoperative Magnetic Reso nance Imaging (MRI). Postoperative follow up patient’s data was collected from computerized data system in outpatient clinics. The extent of surgical tumor resection was obtained by using the Simpson grading scale and depend on the operative note and post-operative radiology films.

Results: All patients data used in this study as age, gender, site of tumor, postoperative radiotherapy and extent of surgical tumor resection. This study included 51 newly diagnosed patients with meningioma (30 females and 21 males, the median age 49 years); 70% of them were in convexity, 100% of cases underwent total surgical resection and postoperative radiotherapy. Recurrence occurred in 22% of cases. Prognostic factors such as age, gender and tumor location and tumor types. As regard meningioma type, anaplastic type had significantly higher recurrence rate compared to patients with atypical meningioma. Yet, no other significant could be detected including demographic data such as age, gender, tumor location.

Conclusion: Patients with an anaplastic meningioma may develop a recurrent tumor than an atypical type. The anaplastic meningioma was a significant risk factor for shorter overall survival and for shorter disease-free survival. Radical surgical excision of the tumor or administration of adjuvant radiotherapy following initial incomplete surgical resection appears crucial for long-term treatment.