Modified Platelet Rich Plasma (PRP) Technique in Repair of Primary Cleft Palate

Abstract

Objectives: Evaluation of the impact of Platelet Rich Plasma (PRP) added during primary repair of the full cleft palate and comparing the results with those obtained without PRP application.
Design: A prospective single randomized study.
Setting: All patients attending at pediatric surgery and otolaryngology departments, Al-Azhar University Hospitals, Cairo, Egypt.
Patients: Forty patients divided into two equal groups. All patients underwent 2- flap technique palatoplasty. Group A; 20 patients had PRP injection (3-5ml injected in each layer) during palatoplasty, while group B; 20 patients without PRP application. All patients were followed up in the out-patient clinic for 13 (12-17) months.
Results: Forty patients presented with complete cleft palate, 25 men and 15 women aged 18 months on average (12-24 months). All patients undergone 2- flap palatoplasty without complications with intraoperative. In group A, no cases of postoperative fistula (0%) after palatal surgery, while fistula occurred in 4 cases (20%) of patients in group B., There was a lower incidence of fistula in group A than in group B (p=0.113).
Conclusions: PRP application is feasible and effective technique. Formation of the fistula following primary palatoplasty is decreased with PRP application.