New Risk Factor for Bronchogenic Carcinoma

Abstract

Introduction: Smoking causes 90% of cases of lung cancer in men and 70-80% of cases in women. Individuals without smoking history have other risk factors e.g. genetic, infectious, air pollution, cooking and heating fumes or radiation. In those patients the most common histology is adenocarcinoma. Complex coronary intervention is associated with significantly higher dose of radiation exposure than diagnostic procedure.
Objective: We aim in this study to show the relationship between X-ray exposure in complex coronary intervention and increase incidence of bronchogenic carcinoma.
Methods: A case control observational study. We recruited 60 cases of bronchogenic carcinoma presented to our facility from March 2012 to march 2019. Some had history of radiation exposure due to complex coronary intervention, compared with randomly selected 60 healthy relatives matched for age, sex and smoking index. Associations between radiation exposure and lung cancer risk were estimated by use of odds ratios. Reported P values are two-sided.
Results: 15 patients with bronchogenic carcinoma had history of radiation exposure due to complex coronary intervention while only 5 patients of controls had been exposed to this form of radiation.
Odd ratio = 3.67, p-value = 0.0257
Conclusion: Complex coronary intervention is associated with significant radiation exposure and increase incidence of bronchogenic carcinoma