Oxidative Stress in the Male Rats Treated with Metronidazole

Basim A Almayahi, Afyaa Sabah Nasir, Shaymaa Hussien Jaber, Methak Aded-musim Goda,

Published on: 2020-01-13

Abstract

Metronidazole is a major antibiotic that is widely used for treating many parasitic illnesses so that many studies have recorded several beneficial effects for the drug. The present study is designing to determine its effect on the hematological blood parameters and antioxidant enzymes in the male white rats. Treatment of rats with metronidazole into two doses include 125 and 250 mg/kg for 30 days, the results show increment in the red blood corpuscles (RBCs), hemoglobin concentration (Hb) and the count of total blood cells (WBCs) but no change in the Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Volume (MCV) and Mean Corpuscular Hemoglobin Concentration (MCHC) values relative to their respective controls. Also, the results show elevated in the antioxidant enzyme (SOD) while reduced in the antioxidant enzyme catalase (CAT) while a significant increase in the malondialdehyde (MDA) in comparison with the control group. In conclusion, metronidazole has many useful effects on the hematological blood parameters and antioxidant enzymes in the male white rats but for a limited time.

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