Oxyskyrin Inhibits the Growth of Murine SV40 Transformed Bone Blastoma Cells in Vitro

Abstract

We test the effects of Oxyskyrin, a secondary metabolite of the lichen Lecanora pseudistera, on the growth of murine SV40 transformed bone blastoma cells in vitro. We find that Oxyskyrin is a potent inhibitor of growth. We also find that Oxyskyrin increases sensitivity of cells to radiation and this effect is significant at radiation intensity lower than the standard intensity of cancer radiotherapy. On the basis of this study, Oxyskyrin shows promise for combined-modality cancer treatment.