Pentaglobin as Adjuvant Therapy for the Management of Sepsis in the Critical Care Unit

Hayder Adnan Fawzi,

Published on: 2020-05-28

Abstract

Background: Sepsis is a life-threatening condition usually characterized by multiple dysfunctions, it is a medical emergency requiring prompt intervention. Since dysregulation of host factor response toward infection is the usual cause of sepsis or septic shock, pentaglobin regulate this process and improve survival, we aimed to investigate the effectiveness of pentaglobin as adjuvant therapy in the management of sepsis.
Methods: Prospective study that involved sixty patients with sepsis, these patients were enrolled to be treated with Pentaglobin (5 ml/kg/day) IV for three days in addition to the standard treatment regimen.
Results: 54 (90%) had survived, there was a significant reduction of their fever, white blood cell counts, tachycardia and tachypnea after treatment with pentaglobin. The most common sites of infection are the lungs. Finally, Gram-negative bacterial infections are the most common cause of sepsis.
Conclusions: The use of pentaglobin as an adjuvant therapy to the standard lines of management with sepsis is safe and beneficial.

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