Presence of Helicobacter pyloriamong Patients with Resen Ischemic Stroke and its Relationwith Severity of Stroke

Abstract

Stroke is acute focal brain dysfunction due to vascular disease. Stroke is the third most common cause of death in the world. Acute occlusion of an intracranial vessel causes a reduction in blood flow to the brain region it supplies. Several studies were done on H. pylori infection, that reported association between H. pylori and endothelial dysfunction, chronic inflammation, dyslipidemia, impaired glucose metabolism, metabolic syndrome, peripheral vascular disease, and coronary artery disease. This study aims to find whether there is an association between H. pylori infection and resent atheroembolic ischemic stroke and if there is any effect on the severity of ischemic stroke. This study was carried out in the Middle Euphrates neurological screen center (MENC) in Al-Najaf city for a period of fourteen months (from January 2015 to February 2016).
This study includes one hundred patients presented with newly diagnosed ischemic stroke (fifty males and fifty female) and one hundred control (patients who are consulted Middle Euphrates neurological screen center for diseases rather than stroke, fifty males and fifty female). The ages of all persons in this study ranging from 40 to 60 years. A brain CT scan (plain) was obtained for all hundred patients that presented with stroke, and acute atheroembolic ischemic stroke was confirmed. For all persons in this study, full history and physical examination were done, blood pressure was measured, the serological method was used in the investigation of H. pylori infection, then, investigated for fasting blood sugar, lipid profile, electrocardiography, and echocardiography. The presence of H. pylori in patients with ischemic stroke was (56%), while (44%) in controls, however, the difference was statistically not significant (p > 0.05). There is a significant association between H. pylori and resent atheroembolic ischemic stroke in diabetic patients. There is no statistically significant association between H. pylori infection and the severity of recent ischemic stroke. This study concluded that there is no significant relationship between H. pylori infection and ischemic stroke after the stratification of other cofounder risk factors.