Quasi-Experimental Study: Intrathecal Analgesia Clonidine vs. Morphine for Immediate Postoperative Pain Management in Column Surgeries

Romero Edward,

Published on: 2022-12-26

Abstract

Introduction: Immediate postoperative pain management is essential for the patient’s greater comfort and early rehabilitation. The goal of this study is to evaluate the immediate analgesic postoperative effect in posterior lumbosacral spine surgery, as well as the adverse effects of the administration of intrathecal analgesia, using Clonidine versus Morphine.

Material and methods: An analytical, quasi-experimental, prospective, longitudinal, comparative, double-blinded intervention study was conducted to compare the efficacy of immediate postoperative intrathecal analgesia in primary posterior lumbosacral spine surgery and the adverse effects. The patients were divided into two previously designated groups. One group received Clonidine 0.5 micrograms/kg and the other group received Morphine 5 micrograms/kg. Intrathecal, intraoperative.

Results: There was a statistically significant difference between better postoperative pain management in the first hours and less vomiting in the group of patients who received intrathecal Clonidine. There was no statistically significant difference between both intrathecal medications in the evaluation of other adverse effects.

Discussion: The use of intrathecal analgesia, has been on the rise over time and more studies have been conducted to see the efficacy of different drugs, different doses, with fewer adverse effects. This study analyzes these variables with a view to finding a better therapeutic option. The advantage is having a representative if a not random sample, strict follow-up, and appropriate statistical analysis.

Conclusion: Intrathecal Clonidine proved to be more effective in immediate postoperative pain management after posterior lumbosacral spine surgery and with fewer adverse effects.

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