Study of Effect of Hepatitis C Virus on some Liver Function

Abstract

Background: Hepatitis C virus (HCV) is a Hepacivirus of the Flaviviridae family, generally concerned with hepatic disorders, including chronic hepatitis that may develop to cirrhosis and hepatocellular carcinoma.
Aim: The aim of this study was to detect changes in some liver function in patients with hepatitis c virus.
Method: The current study is carried out in the health institutes of Al-Muthanna province, including (Al-Hussein Teaching Hospital- Al-Amal Center for renal dialysis, Teaching hospital for geriatrics and pediatrics-Thalassemia Unit, Al-Rumaitha General Hospital, Al-Khader General Hospital, Main Blood bank and Public Health Laboratory). The study included (100) patients with hepatitis c virus and (100) control. The patients and control divided to three groups according to age. The ages were between (10-42) years old (6) ml were drawn from each patient and control. The blood samples allowed to coagulate at room temperature for (15-20) minutes then centrifuged at 3000 rpm for 10 min for separation of serum for estimation of the liver enzymes.
Results: The results for this study indicate a significant decrease at (P<0.05) in albumin level of patients comparing with control in all age groups, also the results showed a significant increase at (P<0.05) in Serum Total Bilirubin (STB), Glutamate Pyruvate Transaminase (GPT), Glutamate Oxaloacetate Transaminase (GOT) and Alkaline Phosphatase (ALP) levels of patients comparing with control in all age groups.