To improve the comorbid families behavior, knowledge, and attitudes about evidence-based options, we undertook an educational intervention. In the current study, we evaluated the knowledge and attitude of the comorbid families about family planning options pre and post informing program. the knowledge and attitudes of the comorbid families about family planning options pre and post educational intervention, from Feb-2015 to April-2016. This is a pre-post intervention survey analysis of seventy-six monogamous married couples. Couples were sequentially enrolled if they met the inclusion criteria of harboring comorbidities when seeking family planning services. we evaluated the participants by using a questionnaire based on the health belief model prior to and following the educational intervention. Education sessions include an educational video program and a question and answer parts. For analyzing our data was used chi-square, paired t-test, Spearman and Pearson’s correlation coefficient. Directed family planning education to couples with comorbidities significantly altered their attitude and knowledge. Counseling led to more informed choice behavior about family planning methods, by prioritizing permanent methods of vasectomy versus tubal ligation, especially after the education intervention (P<0.005). Family planning education and counseling directed to couples with multiple comorbidities should be a priority in health centers because the appropriate contraceptive choice will improve their health literacy and outcomes.