Time to Progression of Early Versus Advanced Breast Cancer in Iraq

Abstract

Background: Breast cancer is the most common cancer in Iraq, in the latest Iraqi Cancer Registry report. Time to progression is an indicator method for primary endpoint in early and advance breast cancer stages.
Objectives: Comparison between early and advance breast cancers, and their characterizers, with calculation of time to progression of early versus advance stages.
Methods: A comparison retrospective analysis study included 702 women with early and advanced breast cancer, at Baghdad Medical City, at period from January 2019 to May 2019. Applied of inclusion criterias, and exclusion criterias for selection. Descriptive statistics were calculated by used mean, standard deviation, and Chi-square. The odds ratio (OR) and to time to progression (TTM) used.
Results: The most common age was above fifth decade. Body mass index, as moderate obesity was prominent measuring. The IDC represented the most histopathology. The T2 was dominant stage, and N1 stage was the common. Women have early breast cancer presented in 54.9%, while advance cancer was 45.1%. The hormonal positive recorded more frequent, and inverse was seen in the HER 2neu. Those comparison data were significantly difference among age, HR positive, and HR+/ HER- subtypes. All linked data between early and advance stages to progression time by a logistic regression model were highly significant association. The time to progression in early stage was 46.7 months, and for advance was 31.3 months (P=0.001).
Conclusions:Comparison points between early and advance cancers reflect a novelty for our study. The interaction between early and advance stage to TTP give additional novelty as it is first end points in Iraqi breast cancer women.