A Case of Sjogren’s Syndrome Associated with Sarcoidosis and Hypercalcemia Related to Secondary Hyperparathyroidism View PDF

^*Amina Mankai
Department Of Internal Medicine, Mongi Slim Hospital, University Of Tunis El Manar, Tunis, Tunisia

^*Corresponding Author:

Amina Mankai
Department Of Internal Medicine, Mongi Slim Hospital, University Of Tunis El Manar, Tunis, Tunisia
Email:amankai@gmail.com

Published on: 2015-03-07

Abstract

A 65-year-old woman suffering from primary Sjogren’s syndrome was admitted to our department of internal medicine for uncontrolled diabetes. Investigations revealed clinical and biological cholestasis with steatotic hepatomegaly and granulomatous hepatitis with eosinophilic necrosis and cholestatic lesions. Taking into consideration, the diagnosis of sarcoidosis, special investigations were performed revealing a hypercalcemia, labial granulomatous lesions of minor salivary glands, a pulmonary restrictive syndrome and bilateral micronodules and lymph nodes of Barety's space. The diagnosis of sarcoidosis was then made and a prednisone therapy started. The course was favorable except for the persistence of hypercalcemia. Hyperparathyroidism with severe vitamin D deficiency were diagnosed.

Keywords

Sarcoidosis; Sjogren’s syndrome; Hypercalcemia; Hyperparathyroidism; Vitamin D deficiency

Introduction

Sarcoidosis is a systemic inflammatory disease characterized by the presence of noncaseating epithelioid granulomas in many organs. Coexistence of sarcoidosis and Sjogren’s syndrome (SS) has been reported occasionally.