A Diffuse Large B cell Lymphoma (DLBCL) With Central Nervous System Involvement in a HIV Positive Patient View PDF

^*Amelia Maria Gaman
Department Of Pathophysiology, University Of Medicine And Pharmacy Of Craiova, Romania

^*Corresponding Author:

Amelia Maria Gaman
Department Of Pathophysiology, University Of Medicine And Pharmacy Of Craiova, Romania
Email:gamanamelia@yahoo.com

Published on: 2015-04-06

Abstract

We present a case of a 18-year-old woman hospitalized in the Clinic of Hematology of Craiova (Romania) in September 2010 for a diffuse large B cell lymphoma-HIV associated, treated with intensive antiretroviral therapy (HAART) and eight cycles of rituximab-CHOP, with a good response (complete remission). After eighteen months, the patient relapsed in the central nervous system and develops a depressive syndrome. Central nervous system involvement is frequent in patients with secondary malignant lymphoma-HIV associated and may be expressed as neurological symptoms and psychiatric manifestations.

Keywords

DLBCL; HIV; Central nervous system involvement

Introduction

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin's lymphoma. Hereditary immune deficiencies (ataxia teleangiectasia, Wiskott-Aldrich syndrome, severe combined immune deficiency) or acquired immune deficiencies (HIV-AIDS) represent risk factors for malignant lymphoma