A Meta-Analysis of the Association between the Q141K ABCG2 Gene Variant and Gout Risk View PDF

^*Hua Yao
Medicine, The First Affiliated Hospital Of Xinjiang Medical University,, China

^*Corresponding Author:

Hua Yao
Medicine, The First Affiliated Hospital Of Xinjiang Medical University,, China
Email:yaohua01@sina.com

Published on: 2015-07-23

Abstract

Gout is an inflammatory disease and genetic factors play a role in gout. ABCG2 is a urate transporter, and an association has been reported between the Q141K variant of ABCG2 and gout risk. Previous studies have demonstrated inconsistent results regarding this association. Therefore, we conducted a metaanalysis to explore the relationship between this variant and gout.

Keywords

Gout; Q141K; Single nucleotide polymorphism; Meta-analysis

Introduction

Gout is a series of recurrent relapsing inflammatory disease. Gout is caused by monosodium urate (MSU) crystals that precipitate in joints and soft tissues. Gout is characterized by intense pain that typically persists for approximately one week. In recent years, the prevalence and incidence of gout has been increasing.