Acrokeratosis Verruciformis of Hopf: Report of a Case of Onset in Adulthood and Review of Literature View PDF

Pablo Zini
Department Of Dermatology, Hospital De Clínicas “José De San Martín”, Faculty Of Medicine, University Of Buenos Aires, Buenos Aires,, Argentina
Juliana Martínez Del Sel
Department Of Dermatology, Hospital De Clínicas “José De San Martín”, Faculty Of Medicine, University Of Buenos Aires, Buenos Aires, Argentina
Dante Chinchilla
Department Of Dermatology, Hospital De Clínicas “José De San Martín”, Faculty Of Medicine, University Of Buenos Aires, Buenos Aires, Argentina
Myriam Dahbar
Department Of Dermatology, Hospital De Clínicas “José De San Martín”, Faculty Of Medicine, University Of Buenos Aires, Buenos Aires, Argentina
Jesica Rios
Department Of Dermatology, Hospital De Clínicas “José De San Martín”, Faculty Of Medicine, University Of Buenos Aires, Buenos Aires, Argentina
^*Graciela Manzur
Department Of Dermatology, Hospital De Clínicas “José De San Martín”, Faculty Of Medicine, University Of Buenos Aires, Buenos Aires, Argentina

^*Corresponding Author:

Graciela Manzur
Department Of Dermatology, Hospital De Clínicas “José De San Martín”, Faculty Of Medicine, University Of Buenos Aires, Buenos Aires, Argentina

Published on: 2026-04-03

Abstract

Acrokeratosis verruciformis (AKV) of Hopf is a rare genodermatosis of autosomal dominant inheritance that is characterized by the presence of keratotic papules of symmetrical arrangement in rubbing areas on the back of the hands and/or feet. There are few cases of sporadic presentation in adulthood. The histopathological study shows the typical “church capitals”. Due to its benign evolution, treatment is indicated at the request of patients for aesthetic reasons. We present a 76-year-old patient with sporadic Hopf’s verruciform acrokeratosis of onset in adulthood.

Keywords

Acrokeratosis, Verruciform acrokeratosis, Hopf, Church capitals, Keratotic papules

Introduction

Hopf ’s verruciform acrokeratosis is a rare genodermatosis characterized by the appearance of keratotic papules on the dorsum of the hands and feet. Described by Hopf in 1931, it has a worldwide distribution and affects all ethnicities, with a higher prevalence in males. It is inherited in an autosomal dominant pattern, so it is common to find several members of a family with the same dermatosis, which is usually presents in childhood. However, cases of sporadic onset in adulthood have been described, without a family history [1-3].

We present the case of a 76-year-old patient with sporadic Hopf ’s verruciform acrokeratosis, with onset in adulthood.