Acute Cytolytic Hepatitis Probably due to Lercadinipine View PDF

Bernard Maroy
Department Of Gastro, 2 Chemin De Frégeneuil, Soyaux, France

Published on: 2014-10-13

Abstract

An 84-years man was treated by fluindione and verapamil. The latter has been changed for lercanidipine and amiodarone. At day 4, started epigatric ache and asthenia and, at day 14, dark urines. Lercanidipine but not amiodarone, has been stopped at day16. Blood tests disclosed GPTx10. US and virus tests were negative. Liver tests reverted to normal within 2 months. Responsibility of lercanidipine seems probable

Keywords

Drug induced; Acute; Cytolytic; Hepatitis lecarnidipine

Introduction

Lecardinipine is an anti-calcic antihypertensive medication, acting through a direct, progressive, relaxation of smooth muscle. An 84-y. old, retired countryman, devoid of any other antecedent of travels, other treatments, comprising OTC and herbs, non-smoker, not-drinker, without any recent close contact with farm animals, suffered a stroke in 2010 with hypertension. He was treated by fluindione and verapamil.