Atropine Intoxication in a Child after Accidental Ingestion of 200 mg Atropine Sulfate - A Case Report View PDF

Abstract

Atropine systemic toxicity may causes the anticholinergic toxidrome including pupillary, mucous membranes, skin, urinary, gastrointestinal, cardiac, and central nervous system symptoms. A 6-year-old boy admitted to the emergency department with agitation, vomiting, and fever with a suspect ingestion of atropine sulfate solution. The patient was hospitalized, intubated, sedated with midazolam and mechanically ventilated. Gastric lavage was performed. After treatment with active charcoal, neostigmine and afterwards physostigmine were administered. Atropine sulfate was detected in the blood sample by using high-performance liquid chromatography-diod array detector method. Patient had supportive care until his symptoms resolved. At the end of the fourth day, patient was discharged in a healthy state except bilateral mydriasis which may continue for a week..

Keywords

Anticholinergic toxicity; Atropine sulfate; Child; HPLC-DAD; Intoxication; Physostigmine