Determination of some Biochemical Marker in Postmenopausal Women with Chronic Periodontitis View PDF

^*Sayran Sattar Saleh
Department Of Chemistry, College Of Science, Kirkuk University, Iraq

^*Corresponding Author:

Sayran Sattar Saleh
Department Of Chemistry, College Of Science, Kirkuk University, Iraq

Published on: 2020-06-03

Abstract

Aim: Menopause, resulting from the permanent cessation of menstrual cycle, acts as the potential risk factor for periodontal diseases. Due to the long life-expectancy, today women live about half of their life after menopause. This study aimed to evaluate, estrogen, estradiol, Leptin, adiponectin, paraoxonase (PON-1), oxidative stress and oxidative stress indices between postmenopausal women with chronic periodontitis (CP) and premenopausal women without CP as control.
Methods: Serum samples were collected to measure the mean levels of the following hormones: cortisol, estradiol, Leptin, adiponectin, as well as to measure biomarkers of oxidative stress including malondialdehyde (MDA), glutathione peroxidase (GPX), and total antioxidant capacity (TAC), and status of antioxidant enzymes (superoxide dismutase (SOD), and Gamma-glutamyl transpeptidase (GGT), and catalase (CAT), levels were estimated in the blood of postmenopausal women with chronic periodontitis (CP) (n=70) and compared with those in age matched premenopausal women without CP as control (n=70).
Results: The serum estrogen, adiponectin, PON1, catalase, TAC, and SOD were higher in controls as compared to cases. Serum leptin, Cortisol, GGT, and MDA levels were found to be higher in cases as compared to controls.
Conclusion: In postmenopausal women, leptin and adiponectin concentrations are substantially correlated with sex hormone and associated with an increased risk of incident of CP. Serum oxidative stress level may be an indicator of worsened chronic periodontitis related to post menopause and the count of metabolic risk factors which causes pathology in this stage of life.

Keywords

Postmenopausal Women; Malondialdehyde; Estrogen

Introduction

Menopause is an uncommon period in a lady’s life. The creation of estrogens changes radically at menopause, that can prompt osteoporosis in skeletal bones, portrayed by the loss of bone mass and decrease of bone thickness, and with a subsequent increment in bone delicacy and helplessness to break. Postmenopausal status is additionally a significant hazard factor for periodontal diseases [1].
Periodontitis is a plaque prompted ailment, the movement of which is affected by altering components, for example, foundational sickness conditions, age, and sociodemographic conditions, periodontitis ordered by its step by step submit bat, yet sooner or later experiences worsening, in which microbial plaque causes periodontal tendon and bone destruction [2-4].
The ebb and flow recommendation for the pathogenesis of periodontal malady stresses on “microbial dysbiosis” wherein a move in the cooperative advantageous microbial networks in the plaque biofilm to pathogenic microorganisms fundamentally represents the inception of periodontal disease [4].
Fat tissue is dynamic endocrine organ that discharges numerous metabolically dynamic peptide hormones, cytokines, chemokines and adipokines, for example, leptin, visfatin, resistin, apelin, omentin, sex steroids, and different development factors are cell flagging proteins. Adipokine dysregulation seems to play an assume a focal job in the improvement of insulin opposition, the principle pathologic instrument of numerous metabolic and vascular diseases [5,6].
Leptin is a hormone-like protein, which from the start stood apart due to its enormous activity in coordinating weight and processing of the human body. Leptin impacts the body’s obstruction parts, including Immune system microorganisms, macrophages and endothelial cells. Thusly, a couple of masters have named it a cytokine [7].
Adiponectin a 244-amino destructive protein, is one of the promptest adipokines produced from fat tissue, has moderating, and insulin-honing properties, and antagonistic to atherosclerotic administrator that chokes cardiovascular danger which may be credited to its quieting properties. It controls IL-6 and TNF-creation by macrophages and grows the production of critical quieting factors, for instance, IL-10 or IL-1RA by human monocytes, macrophages, and dendritic cells [8,9]. Thus, the reason for this investigation was to decide the impact of the periodontitis on serum leptin, and adiponectin, oxidative pressure and cell reinforcement status levels in postmenopausal ladies.