Endothelial Function, Insulin Resistance, Serum Adiponectin Level in Rheumatoid Arthritis Females with Renal Dysfunction and Its Dynamics with L-Arginine Aspartate Supplementation View PDF

^*Oksana Sirenko
Department Of Inner Medicine, Dnipropetrovsk Medical Academy Of Health Ministry Of Ukraine, Dnipro, Ukraine

^*Corresponding Author:

Oksana Sirenko
Department Of Inner Medicine, Dnipropetrovsk Medical Academy Of Health Ministry Of Ukraine, Dnipro, Ukraine
Email:oksanasirenko@i.ua

Published on: 2017-12-29

Abstract

To evaluate endothelial function, insulin resistance, serum adiponectin level in rheumatoid arthritis females with renal dysfunction and its dynamics with the L-Arginine aspartate supplementation. 69 females with rheumatoid arthritis (RA) and renal dysfunction were enrolled. Patients were divided into group received L-Arginine aspartate and placebo group. Serum insulin, adiponectin were measured at the baseline and after 4 weeks. The level of insulin resistance, GFR was calculated. Determination of flow mediated vasodilation was performed at the baseline and after 4 weeks.

Keywords

Rheumatoid arthritis; Renal dysfunction; Endothelial dysfunction; L-Arginine

Introduction

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases in the general population [1]. It has been established that the leading cause of death in RA pts is atherosclerotic cardiovascular diseases, primarily ischemic heart disease [2]. However, there are a number of scientific questions required further studies. Thus, the features of atherosclerotic lesions of arteries in various clinical RA variants, the influence of risk factors, comorbid diseases and antirheumatic drugs on a therogenesis are not completely studied [3-5].