Familial Y Micro deletion with Cleft Lip View PDF

^*Miguel Cano
Medicine, The University Of Texas Medical Branch , Texas, United States

^*Corresponding Author:

Miguel Cano
Medicine, The University Of Texas Medical Branch , Texas, United States
Email:cpt.ajcano.md1@gmail.com

Published on: 2016-04-10

Abstract

Cleft lip and cleft palate are frequent congenital malformations that occur as isolated presentations or as a constellation of symptoms with other genetic complications or as part of a specific genetic syndrome. However, there have only been few reports of cleft lip or palate with Y chromosome abnormalities. We report a rare case of familial Yq11.22-Yq11.23 micro deletion with cleft lip and palate.

Keywords

Chromosome Y deletion; Cleft lip; Cleft palate

Introduction

The most common craniofacial malformation identified in the newborn is the orofacial cleft, which consists of cleft lip with or without cleft palate (CL/P) or isolated cleft palate (CP). They can occur as part of a syndrome involving multiple other organs or as an isolated malformation, although most studies suggest that about 70 percent of cases of CL/P and 50 percent of CP are non-syndrome. Although both congenital anomalies result in malformation of the mid face, CL/P and CP differ with respect to embryology, etiology, candidate genes, associated abnormalities, and recurrence risk.