Features of Cytokine Profile in Patients with Progressive TB-Induced Pulmonary Fibrosis Characterized by Various Intensities of Pulmonary Destructive Changes View PDF

^*Viacheslav Yu Kravtsov
Medicine, Pushkin Leningrad State University, Saint Petersburg, Russian Federation

^*Corresponding Author:

Viacheslav Yu Kravtsov
Medicine, Pushkin Leningrad State University, Saint Petersburg, Russian Federation
Email:kvyspb@mail.ru

Published on: 2016-02-28

Abstract

Production of pro- and anti-inflammatory cytokines (IFN-γ, IL-2, TNF-α, IL-8, IL-4, IL-10) in patients with pulmonary TB infection with various spread and severity of the process were investigated in in vitro PPD- and PHA-stimulated peripheral blood mononuclear cells (PBMCs). It was demonstrated that each type of MDR-TB lung fibrosis is determined by specific traits of a multilevel cytokine network functioning according to activity of cytokine-producing cells.

Keywords

Tuberculosis; Multidrug-resistant tuberculosis; Phytohemagglutinin; Interleukin

Introduction

Prevalence of multidrug-resistant TB-infection (MDR-TB), which results in development of severe progressive course of TB-process, is characterized by rapid generalization, greater spreading, immunocompromised state and the lack of effect from the administered standard anti-TB therapy.