Improve in Neurogenesis with Socialization can Reduce Behaviors that are Related to Poor Prognosis in Withdrawal Period in Male Rats View PDF

^*Morteza Karimian
Department Of Physiology, Tehran University Of Medical Sciences, Tehran, Iran, Islamic Republic Of

^*Corresponding Author:

Morteza Karimian
Department Of Physiology, Tehran University Of Medical Sciences, Tehran, Iran, Islamic Republic Of
Email:karimian@tums.ac.ir

Published on: 2015-09-05

Abstract

Morphine withdrawal period is associated with a wide variety of problems. Neurogenesis seems necessary for brain functions. Socialization is a lifelong process that helps getting behavioural norms from society. The aim of this study is to investigate if better neurogenesis in socialization can alleviate problems encountered during withdrawal period.

Keywords

Neurogenesis; Sucrose; Salt; Withdrawal; Isolation; Socialization; Emotional reactivity; Memory

Introduction

Substance abuse is a complex and devastating disorder accompanied by many adverse effects. Addiction cannot be always managed successfully which results in enormous financial and social burden. Relapse to substance abuse is often attributed to mesolimbic dopamine system whose efferent and afferent connections are the neural substrate for the rewarding effects of drugs of abuse.