Lactate Dehydrogenase Concentration in Different Pediatrics Age Groups

*Abbas Hendi Najm Al-Mihyawi
Department Of Pediatrics, Abu Ghraib General Hospital, Baghdad Alkarkh Health Directorate, Ministry Of Health/Environment, Baghdad, Iraq

*Corresponding Author:
Abbas Hendi Najm Al-Mihyawi
Department Of Pediatrics, Abu Ghraib General Hospital, Baghdad Alkarkh Health Directorate, Ministry Of Health/Environment, Baghdad, Iraq
Email:Medicalresearch79@yahoo.com

Published on: 2022-06-20

Abstract

Normalisation of blood LDH level is associated with improved survival in many studies conducted in adults, in children and neonate. The study aimed to estimate the LDH for different pediatrics age groups. An observational study was conducted at Pediatrics ward, Abu Ghraib General Hospital, from January 2018 to December 2019. Study sample included 250 children, their age ranged from 1 day to 16 years. Children of both gender with these age groups admitted to ward, and blood LDH were calculated. The maternal history, fever, umbilical infection, SOB, hypoxia, sepsis, and respiratory distress syndrome (RDS) were documented accordingly. LDH measured as followed: New born: 160 to 450 units per litre (units/L) and child: 60 to 170 units/L. We divided sample to two-groups, newborn babies (1 day to 1 year) and chid (>1 year to 16 years), and the study variables were documented. The LDH concentration and variables correlation calculated. The prognostic value of serial serum LDH monitoring for predicting morbidity and mortality in sick children is confirmed. There is a correlation, although very clear, between the plasma LDH levels with infection, asphyxia, and RDS.

Keywords

LDH; RDS; SOB; Hypoxia

Introduction

Monitoring of tissue perfusion markers in ill children is necessary for early recognition of disease which will enable to start an appropriate and timely management. Lactate dehydrogenase (LDH) has been considered as a marker of tissue damage. Normalisation of blood LDH level is associated with improved survival in many studies conducted in adults [1], in children [2,3] and neonate [4-7]. LDH concentrations at the moment of the pediatrics ages may be have a positive correlation with the disease prognosis [8,9]. Several measurements of LDH concentrations are valuable in assessing the prognosis and response to treatment [10,11]. Moreover, lactate dehydrogenase (LDH) is an intracellular enzyme that responds to energy shortages in all organs. Therefore, plasma LDH is also an indicator of body tissue hypoxia [12].
The study aimed to estimate the LDH for different pediatric age groups.

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