Myelomeningocele Associated with Deletion of 22q11 and Normal Posterior Fossa: Prenatal Diagnosis

*Ladan Younesi
Medicine, Shahid Akbar Abadi Clinical Research Development Unit , Iran University Of Medical Sciences, Tehran, Iran, Islamic Republic Of

*Corresponding Author:
Ladan Younesi
Medicine, Shahid Akbar Abadi Clinical Research Development Unit , Iran University Of Medical Sciences, Tehran, Iran, Islamic Republic Of
Email:younesi.l@iums.ac.ir

Published on: 2019-10-07

Abstract

Keywords

Neural tube defect; Myelomeningocele; Chiarimalformation; Deletion of 22q11

Introduction

Neural tube defects (NTDs) are structural defects secondary to abnormal neural tube closure that occurs during early fetal development. NTDs are divided into two major groups: (a) defects involving cranial structures, such as anencephaly and encephalocele; (b) defects at the level of the spinal cord (spina bifida) [1]. Spina Bifida Myelomeningocele (SBM) is the most common nonlethal neural tube defect (NTD) in North America, affecting three to five per 10,000 births per year [2]. The defect is characterized by protrusion of the spinal cord, meninges, and nerve roots through an opening in the spine.

scroll up