Occurrence of Congenital Heart Disease among Children with Down syndrome: What is the Influence of Maternal Age? View PDF

^*Adeola B Animasahun
Medicine, Lagos State University, Nigeria

^*Corresponding Author:

Adeola B Animasahun
Medicine, Lagos State University, Nigeria
Email:deoladebo@yahoo.com

Published on: 2017-04-14

Abstract

The occurrence of Down syndrome is strongly dependent on maternal age and incidence varies at various maternal ages. This incidence may differ from one country to another according to the social and environmental factors predominant in such countries. The study aims to document the prevalence of congenital heart defects in patients with Down syndrome, identify the association between maternal age and occurrence of congenital heart disease among these subjects

Keywords

Down syndrome; Children; Echocardiography; Congenital; Heart; Disease; Maternal; Age

Introduction

Down syndrome, also known as trisomy 21 is the best known chromosomal aneuploidy disorder occurring in humans. It has multiple systemic manifestations. It results from three cytogenic variants: three full copies of chromosome 21 account for 95% due to meiotic nondisjunction, unbalanced translocation three to four percent mosaicism one to two percent.