The Effects of Avocado Fruit Methanolic Extract on Human Gastric Adenocarcinoma Cell Line in Comparison with Peripheral Blood Mononuclear Cells View PDF

^*Saeid Abediankenari
Medicine, Immunogenetic Research Center, Mazandaran University Of Medical Science, Sari, Iran, Islamic Republic Of

^*Corresponding Author:

Saeid Abediankenari
Medicine, Immunogenetic Research Center, Mazandaran University Of Medical Science, Sari, Iran, Islamic Republic Of
Email:abedianks@razi.tums.ac.ir

Published on: 2015-08-15

Abstract

Gastric cancer is the second leading cause of cancer related deaths in worldwide. Adenocarcinomas comprise the majority of stomach cancers that are usually diagnosed in the late stage with low survival rate and have prompted considerable interest in neo adjuvant therapies to improve longevity. It has been reported that neoplasias in the gastrointestinal system are mostly due to change in dietary habits. The therapeutic effect of herbal materials in suppression of cancer cell proliferation was shown. In this study, we evaluated the efficiency of methanolic extract of avocado fruit on the inhibition of growth of gastric adenocarcinoma cell line, in comparison with normal cells.

Keywords

Methanolic extract; Gastric adenocarcinoma; Avocado; Fruit

Introduction

Gastric cancer is the second common cause of cancer-related death worldwide. Its 5-year survival rate is low ranging from 10 to 19%. Some genetic and environmental factors were shown to be linked to cancer. Since gastric adenocarcinoma is usually detected in an advanced stage that poorly respond to conventional therapeutic modalities such as palliative surgery, chemotherapy and radiation, thus searching novel therapeutic approaches is a necessity.