The Expression of BCL-G in Leukemia and Gastrointestinal Tissues View PDF

^*Faris Q Alenzi
Department Of Immunology, College Of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Saudi Arabia

^*Corresponding Author:

Faris Q Alenzi
Department Of Immunology, College Of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Saudi Arabia
Email:qalenzi@ksu.edu.sa

Published on: 2016-03-23

Abstract

BCL-G is a novel protein of Bax (BCL-G associated protein X) inducing caspase-mediated apoptosis. These proteins are involved in regulating apoptosis both in normal, and in neoplastic cells although their cellular and tissue distribution is currently unknown. Accordingly, the objective of the current study was to ascertain and define the pattern of distribution and expression of BCL-G in normal and malignant gastrointestinal human tissues.

Keywords

Leukemia; Gastrointestinal tissues; BCL-G

Introduction

BCL-G is highly conserved in humans as well as many mammals encoding BCL-GL and BCL-GS, where the former is was displayed widely in many tissues, the latter detected only in testis by PCR. BCL-GS was found to contain only BH3 domain thus able to induce apoptosis, while, BCL-GL, doesn’t induce apoptosisa.