The Role of Simillimum in Homeopathy

Homeopathy, a method of natural healing, is based on the idea ‘let like be cured by like’, known as the Law of Similars. It is the first-known process for targeted treatment in medicine. Homeopathy is a system of natural medicine founded on ancient principles. The Law of Similars says that a disease can be cured with a substance that causes the same symptoms of the illness in healthy people. This was proposed by Samuel Hahnemann and published in his well-known work “The Organon of the Healing” [1]. The elements of homeopathic treatments were often discussed in the literature, although its basis, the mechanism of action, and the scientific confirmation of their effectiveness have never been clearly stated. Homeopathy was also discussed in books by Clarke JH (1905) [2], Bellavite P, et al. (2002) [3], and Vithoulkas G (2002) [4].
In the past, researchers have put forward various theories about the properties and working of homeopathy and used several motives and models for this interdisciplinary field of science [3,4]. Later, homeopathy was supposed to be associated with chemical thermodynamics [5]. The basic elements of chemical thermodynamics were introduced in homeopathy after considering the definition of disease described by Drofenik M (2018) [6]. He linked the healthy state with the tuned state and the diseased state with the attuned state and proposed an equilibrium between the two. Accordingly, the definition of treatment in the thermodynamic model is defined as the change of the equilibrium between the attuned (diseased) and tuned (healthy) state [7].
The basis for the use of homeopathy in the treatment of diseases is based on the balance between healthy and diseased states, recognized by finding a remedy that triggers the symptoms of the same disease in healthy people.
All other diseases and/or symptoms do not fall under the purview of homeopathy if explained using the thermodynamic model.
Hahnemann emphasized the Law of Similars and confirmed the usefulness of this way of ancient healing through fruitful experimental work [1]. In the interpretation of the Law of Similars (LS), the Law of mass action (LMA) was included [7]. Further consideration highlighted the importance of kinetics in the limited space of the human cell, where chemical equilibrium is restricted by the kinetics of successful molecular collisions. This leads to the paradox that by reducing the concentration of the remedy consumed, the change of equilibrium and healing can be improved [8].
The all-inclusive aspect of homeopathy [9] highlighted one of the most significant properties of homeopathy, i.e., that the disease-causing compound in a healthy person, i.e., Simillimum, must have the same chemical composition as the compound causing the sickness in ill people. This paper presents the main evidence to confirm this postulate.