Determination of some Biochemical Marker in Postmenopausal Women with Chronic Periodontitis

Abstract

Aim: Menopause, resulting from the permanent cessation of menstrual cycle, acts as the potential risk factor for periodontal diseases. Due to the long life-expectancy, today women live about half of their life after menopause. This study aimed to evaluate, estrogen, estradiol, Leptin, adiponectin, paraoxonase (PON-1), oxidative stress and oxidative stress indices between postmenopausal women with chronic periodontitis (CP) and premenopausal women without CP as control.
Methods: Serum samples were collected to measure the mean levels of the following hormones: cortisol, estradiol, Leptin, adiponectin, as well as to measure biomarkers of oxidative stress including malondialdehyde (MDA), glutathione peroxidase (GPX), and total antioxidant capacity (TAC), and status of antioxidant enzymes (superoxide dismutase (SOD), and Gamma-glutamyl transpeptidase (GGT), and catalase (CAT), levels were estimated in the blood of postmenopausal women with chronic periodontitis (CP) (n=70) and compared with those in age matched premenopausal women without CP as control (n=70).
Results: The serum estrogen, adiponectin, PON1, catalase, TAC, and SOD were higher in controls as compared to cases. Serum leptin, Cortisol, GGT, and MDA levels were found to be higher in cases as compared to controls.
Conclusion: In postmenopausal women, leptin and adiponectin concentrations are substantially correlated with sex hormone and associated with an increased risk of incident of CP. Serum oxidative stress level may be an indicator of worsened chronic periodontitis related to post menopause and the count of metabolic risk factors which causes pathology in this stage of life.