The Combined Use of Intracaval and Oral Calcium for the Treatment of Hereditary Vitamin D Resistant Rickets (HVDRR) View PDF

^*Abdulmoein Eid Al-Agha
Department Of Pediatrics, King Abdulaziz University, Jeddah, Saudi Arabia

^*Corresponding Author:

Abdulmoein Eid Al-Agha
Department Of Pediatrics, King Abdulaziz University, Jeddah, Saudi Arabia
Email:aagha@kau.edu.sa

Published on: 2014-08-04

Abstract

Hereditary vitamin D resistant rickets (HVDRR), also known as vitamin D-dependent rickets type II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia.To study the success of our designed protocol of continuous high dose intracaval, oral calcium and phosphate for the treatment of HVDRR.

Keywords

Rickets; Hereditary vitamin D resistance rickets; 1, 25-Dihydroxy vitamin D

Introduction

The term ‘vitamin D resistant rickets’ was first used in 1937 by Albright et al., who described a form of rickets requiring large doses of vitamin D for healing of nutritionally deficient rickets. HVDRR is a rare form of autosomal recessive disorder often caused by mutation on vitamin D receptor gene preventing normal physiological response to 1,25(OH)2 vitamin D